Cancer is a complex disease involving both genetic and epigenetic alterations that affect a large number of genes, proteins and signalling networks during tumor progression. Normal cells require certain characteristics, i.e. hallmarks, in order to become malignant.
The Cancer Hallmarks Analytics Tool (CHAT) allows users to quickly and easily analyze the strength of association between terms of interest and the hallmarks of cancer in the literature based on a text-mining analysis of tens of million of PubMed abstracts.
You can find CHAT here: http://chat.lionproject.net/
This work is a collaboration with Karolinska Institutet (Institute of Environmental Medicine).